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Antioxidants are molecules that slow or
prevent the oxidation of other molecules. Oxidation
is a chemical reaction that transfers electrons from
a substance to an oxidizing agent. Oxidation
reactions can produce free radicals, which start
chain reactions that damage cells. Antioxidants
terminate these chain reactions by removing radical
intermediates, and inhibit other oxidation reactions
by being oxidized themselves. As a result,
antioxidants are often reducing agents such as
thiols or polyphenols.
Although oxidation reactions are critical for
life, they can also be damaging; hence, plants and
animals maintain complex systems of multiple types
of antioxidants, such as glutathione, vitamin C, and
vitamin E as well as enzymes such as catalase,
superoxide dismutase and various peroxidases. Too
low levels of antioxidants or inhibition of the
antioxidant enzymes causes oxidative stress and may
damage or kill cells.
As oxidative stress has been implicated in the
pathogenesis of many human diseases, the use of
antioxidants in pharmacology is intensively studied,
particularly as treatments for stroke and
neurodegenerative diseases. However, it is unknown
whether oxidative stress is the cause or the
consequence of such diseases. Antioxidants are also
widely used as ingredients in dietary supplements in
the hope of maintaining health and preventing
diseases such as cancer and coronary heart disease.
Although some studies have suggested antioxidant
supplements have health benefits, other large
clinical trials did not detect any benefit for the
formulations tested, and excess supplementation may
occasionally be harmful. In addition to these uses
in medicine, antioxidants have many industrial uses,
such as preservatives in food and cosmetics and
preventing the degradation of rubber and gasoline.
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